As other answers have noted, you cannot change an existing tuple, but you can always create a new tuple (which may take some or all items from existing tuples and/or other sources).
For example, if all the items of interest are in scalar variables and you know the names of those variables:
def maketuple(variables, names): return tuple(variables[n] for n in names)to be used, e.g, as in this example:
def example(): x = 23 y = 45 z = 67 return maketuple(vars(), 'x y z'.split())of course this one case would be more simply expressed as (x, y, z) (or even foregoing the names altogether, (23, 45, 67)), but the maketuple approach might be useful in some more complicated cases (e.g. where the names to use are also determined dynamically and appended to a list during the computation).